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PDE-5 selective inhibitor. Inhibition of PDE-5 increases cGMP activity, which increases vasodilatory effects of NO. Effective in men with mild-to-moderate ED. Take on an empty stomach approximately 1 h before sexual activity. Sexual stimulation is necessary to activate response. The increased sensitivity for erections may last 24 h. Available as 25-, 50-, and 100-mg tablets. Onset of action varies from 15-60 min, with a duration of action of 4-6 h. Half-life is 4-5 h.
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Erectile dysfunction (ED) is the inability of a man to achieve or maintain an erection sufficient for his sexual needs or the needs of his partner. Most men experience this at some point in their lives, usually by age 40, and are not psychologically affected by it.
Alprostadil (Caverject Injection, Edex Injection, MUSE Pellet)
During the period following the licensing of sildenafil for use in ED, an increase in the number of patients seeking treatment for heretofore-untreated ED was widely anticipated. This institution did not find an increase in the number of men referred with ED in the year following 14 September 1998, compared to the year preceding this date. It is not clear though, if this anticipated increase in the number of men with ED have been dealt with in the primary care. Considering that the referral pattern from primary to secondary care has not changed in this institution, we do not feel that this has happened.
A loss of pubic or armpit hair and an enlargement of the breasts.
Don't rely on alcohol or drugs to reduce stress.
QUESTION: I am 55 years old and have trouble getting and maintaining erections. Is this a common problem in men of my age? I know that there are various medications available, can you explain the differences between them?
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However, because people with diabetes also tend to have problems with their heart, these medications may not be appropriate and cause dangerous interactions with your heart medicine. Talk to your doctor to determine what treatment is best.
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Alprostadil, PGE1, has been formulated into a small suppository that can be inserted into the urethra. In a selected group of men, the agent was effective in 65%. This agent may be effective in men with vascular disease, diabetes, and status post prostate surgery. This is a useful agent for men who do not want to use self-injections or for men in whom oral medications have failed. It has been successfully used together with sildenafil in cases in which each agent alone failed. Few adverse effects occur, and the most common is a painful erection and urethral burning, which occurs in less than 10% of the patients.
Are you experiencing a lot of stress?
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Sildenafil, a potent PDE-5 inhibitor has been studied extensively in the context of clinical trials. To date its profile as a safe treatment option in the management of ED remains unchanged. This study aimed mainly at recording the acceptance of the drug, its efficacy and safety profile outside the scope of a trial i.e., in a study without any stringent exclusion criteria.
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